The progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome
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چکیده
منابع مشابه
The progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome
BACKGROUND Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation in progesterone receptor polymorphism with risk of ovarian and breast cancer have concentrated on a variant known as PROGINS. METHODS Ninety-five young women with PCOS and 99 ...
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OBJECTIVE: Some data are available on the association between components of the insulin resistance syndrome and serum ferritin. Insulin resistance is observed in patients with polycystic ovary syndrome (PCOS) We hypothesize that body iron stores might be increased in these women. MATERIALS AND METHODS: Two hundred and six people (103 PCOS patients and 103 healthy women who were matched for a...
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Introduction: Polycystic ovary syndrome is one of the most common causes of infertility. 6 to 8 percent of women of childbearing age have this endocrine disorder. Biochemical abnormalities in these patients lead to imbalance of female hormones and increased androgens, which can have consequences such as menstrual cycle disorder, hirsutism, acne vulgaris and androgenic alopecia. Despite the long...
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OBJECTIVE This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors,...
متن کاملAssociation Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome
Background: Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS). Objective: This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α gene and biochemical factors in women with PCOS. Methods: In this case-control study, participants w...
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ژورنال
عنوان ژورنال: Cardiovascular Diabetology
سال: 2007
ISSN: 1475-2840
DOI: 10.1186/1475-2840-6-29